The importance of maternal ischemia modified albumin, non stress test and doppler ultrasonography in foreseeing perinatal asphyxia

Ischemia modified albumin in foreseeing perinatal asphyxıa

Authors

  • Ferruh Acet Ege University Faculty of Medicine, Gynecology and Obstetrics, Izmir, Turkey https://orcid.org/0000-0003-0628-0368
  • Volkan Emirdar Department of Obstetrics and Gynecology, Izmir Economy University Medicalpark Hospital, İzmir https://orcid.org/0000-0003-4973-2563
  • Murat Celiloğlu Dokuz Eylul University Hospital, Department of Obstetrics and Gynecology, Izmir, Turkey
  • Merve Akış Department of Medical Biochemistry, Balikesir University Faculty of Medicine, Balıkesir
  • Gül İşlekel Department of Medical Biochemistry, Dokuz Eylül University Faculty of Medicine, İzmir https://orcid.org/0000-0002-0416-1325

DOI:

https://doi.org/10.46328/aejog.v3i3.98

Keywords:

ischemia, fetal asphyxia, preeclampsia, non stress test, doppler ultrasonography

Abstract

Background: The aim of this study is to evaluate the importance of ischemia changed albumin, in foreseeing fetal asphyxia and comparing it between normal and preeclamptic pregnant.

Method: We planned our study as a prospective case-controlled study between May 2011 and June 2013. We recruited 104 pregnant women complicated by preeclampsia and 110 healthy pregnant women in the study. Doppler ultrasonography, non-stress test and fetal biometric measurements were performed. Venous blood samples taken to measure ischemia modified albumin (IMA). The presence of fetal hypoxia/acidosis was analyzed by conducting post-natal cord blood gas examination and 1.-5. minutes APGAR scoring.

Results: Women with preeclampsia had higher IMA compared to controls. The correlations between umbilical artery doppler systolic/diastolic (S/D) ratio, brain sparing effect, non stress test and IMA analyzed. We have found IMA statistically high when S/D ratio is above 2 standard deviations (preeclampsia; 11.83±1.33 vs 19.62±1.56 p<0.001, control; 10.28±1.57 vs 18.09±2.13 p<0.001) or brain sparing effect started (preeclampsia; 25.59±2.48 vs 9.16±1.99 p<0.001, control; 16.37±1.97 vs 6.72± 1.53 p<0.001) or abnormal NST findings occurred (preeclampsia; 10.69±1.92 vs 20.72±1.15 p<0.001, control; 7,42±1,94 vs 9,72±2,19 p<0.001).

Conclusions: Maternal IMA levels are found high in preeclamptic pregnant women and it can be used as a biomarker for determining fetal wellbeing.

Author Biographies

Ferruh Acet, Ege University Faculty of Medicine, Gynecology and Obstetrics, Izmir, Turkey

¹M.D., Specialist Ege University Faculty of Medicine, Gynecology and Obstetrics, Izmir, Turkey

Murat Celiloğlu, Dokuz Eylul University Hospital, Department of Obstetrics and Gynecology, Izmir, Turkey

3Prof, Dokuz Eylul University Hospital, Department of Obstetrics and Gynecology, Izmir, Turkey

Merve Akış, Department of Medical Biochemistry, Balikesir University Faculty of Medicine, Balıkesir

4 Balikesir University, Faculty of Medicine, Department of Medical Biochemistry, Balikesir, Turkey

Gül İşlekel, Department of Medical Biochemistry, Dokuz Eylül University Faculty of Medicine, İzmir

5 Dokuz Eylul University, Faculty of Medicine, Department of Medical Biochemistry, Izmir, Turkey

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Published

2021-12-22

How to Cite

1.
Acet F, Emirdar V, Celiloğlu M, Akış M, İşlekel G. The importance of maternal ischemia modified albumin, non stress test and doppler ultrasonography in foreseeing perinatal asphyxia: Ischemia modified albumin in foreseeing perinatal asphyxıa. Aegean J Obstet Gynecol [Internet]. 2021 Dec. 22 [cited 2022 Jan. 16];3(3):68-72. Available from: https://aejog.com/index.php/aejog/article/view/98