The Effect of an antioxidant agent-multivitamin complex food supplement on spermiogram in infertile men
Keywords:male infertility , astaxhantin, oxidative stress, spermiogram
Oxidative stress (OS) occurs due to overproduction of reactive oxygen radicals (ROS) or weakening of anti-oxidant mechanisms and may harm fertility. Our study aimed to investigate the effects of combined support therapy containing antioxidant agents and vitamin complexes on fertility.
In this retrospective case-control study, 300 randomly selected infertile men were included. For four months, the effect of daily intake of an antioxidant-multivitamin complex containing astaxhantin (5mg), Coenzyme Q10 (100mg), L-Arginine (250mg), L-Carnitine (250mg), Selenium (100mcg), Zinc (10mg), Folic acid (400mcg), Vitamin E (100mg) and Vitamin C (100mg) on spermiogram parameters was investigated.
Semen hacminde (2.21 ml -3.05 ml; p=.004), sperm konsantrasyonunda (9.60 milyon/ml -14.10 milyon/ml; p=.000), ileri hareketli sperm sayısında (%16.50 -%26.65; p=.000) ), sperm canlılık oranında (%48 - %68; p=.001) beslenme desteği alan hastalarda istatistiksel olarak anlamlı artış bulundu. Ayrıca tedavinin anormal morfolojiye sahip hasta sayısında (Kruger kriterlerine göre normal morfolojiye ulaşamayan hastaların en az %4'ü) anlamlı azalma (%77 - %61; p=.002) sağladığı belirlendi. ).
Astaxhantin, KoQ10, L-arjinin, L-karnitin, selenyum, çinko, E ve C vitaminleri içeren antioksidan-multivitamin içerikli besin takviyelerinin semen hacmi, sperm morfolojisi, canlılık ve motilite üzerinde anlamlı iyileşme sağladığı belirlendi. Bu bağlamda antioksidan-multivitamin kompleksinin erkek kısırlığında destekleyici tedavi için gıda takviyesi olarak kullanılabileceğini öngörüyoruz.
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