Immunolocalization of FOXP3, JAK1 and STAT5 in Preeclamptic, Intrauterine Growth Restricted and Gestational Diabetic Human Placentas

Authors

  • Volkan Emirdar Department of Obstetrics and Gynecology, Izmir Economy University School of Medicine Izmir, Turkey https://orcid.org/0000-0003-4973-2563
  • Gulcin Ekizceli Department of Histology and Embryology, Istanbul Health and Technology University Faculty of Medicine, Istanbul, Turkey https://orcid.org/0000-0001-9513-5706
  • Yagmur Dilber Department of Medical Biotechnology, Akdeniz University School of Medicine, Antalya, Turkey https://orcid.org/0000-0002-7451-2389
  • Sevinc Inan Department of Histology and Embryology, Izmir Economy University School of Medicine, Izmir, Turkey https://orcid.org/0000-0003-4712-2366
  • Muzaffer Sanci Department of Obstetrics and Gynecology, Izmir Tepecik Training and Research Hospital, Izmir, Turkey

DOI:

https://doi.org/10.46328/aejog.v3i3.101

Keywords:

preeclampsia, intrauterin growth restriction, gestational diabetes mellitus, FOXP3, JAK1 and STAT5 receptors

Abstract

Objective: The aim of the study to show the relation of  T cells in placental villous fragments with FOXP3,JAK1 and STAT5  receptors in different conditions such as   GDM, PE and IUGR placental tissues. 

Methods: Specimens of ten(10) diabetic placentas, ten(10) preeclamptic, ten(10) intrauterine growth restricted placentas  and ten(10) control placentas were collected by systematic uniform random sampling. Immunohistochemical detections of FOXP3, JAK1 and STAT5 were performed in histological sections for each group’s placental tissue. The H-score value was derived for each specimen by calculating the sum of the percentage of syncytiotrophoblast and syncytial nodes in placenta and intervillus area. They were categorized by intensity of staining, multiplied by its respective score.

Results: FOXP3, JAK1 and STAT5 immunoreactivity comparisons are shown in four groups of placentas. FOXP3 immunoreactions significantly increase in GDM group.  JAK1 and STAT5 immunoreactions significantly decrease in PE group. STAT5 immunoreactivity was detected crucially increase  in GDM group.

Discussion: The results showed that in different conditions such as PE,GDM and IUGR,  T cells in   placental villous fragments have relation with FOXP3,JAK1 and STAT5  receptors and that FOXP3 can inactivate the PE and IUGR in the placental tissue. We have also confirmed as other studies that  JAK-STAT pathway plays important role in PE,IUGR and GDM placental tissue.

Author Biographies

Gulcin Ekizceli , Department of Histology and Embryology, Istanbul Health and Technology University Faculty of Medicine, Istanbul, Turkey

Department of Histology and Embryology, Istanbul Health and Technology University Faculty of Medicine, Istanbul, Turkey

Yagmur Dilber , Department of Medical Biotechnology, Akdeniz University School of Medicine, Antalya, Turkey

Department of Medical Biotechnology, Akdeniz University School of Medicine, Antalya, Turkey

Sevinc Inan , Department of Histology and Embryology, Izmir Economy University School of Medicine, Izmir, Turkey

Department of Histology and Embryology, Izmir Economy University School of Medicine, Izmir, Turkey

Muzaffer Sanci , Department of Obstetrics and Gynecology, Izmir Tepecik Training and Research Hospital, Izmir, Turkey

Department of Obstetrics and Gynecology, Izmir Tepecik Training and Research Hospital, Izmir, Turkey

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Published

2021-12-22

How to Cite

1.
Emirdar V, Ekizceli G, Dilber Y, Inan S, Sanci M. Immunolocalization of FOXP3, JAK1 and STAT5 in Preeclamptic, Intrauterine Growth Restricted and Gestational Diabetic Human Placentas. Aegean J Obstet Gynecol [Internet]. 2021 Dec. 22 [cited 2022 Sep. 26];3(3):73-7. Available from: https://aejog.com/index.php/aejog/article/view/101