Ovarian Hilus Cell Hyperplasia and Sertoli-Leydig Cell Tumor in a Patient with Postmenopausal Virilization: a Rare Case Report

Authors

  • Begum Ertan Obstetrics and Gynecology, Dokuz Eylul University https://orcid.org/0000-0002-0370-7509
  • Eyüphan Ozgozen Department of Obstetrics and Gynecology, Dokuz Eylul University School of Medicine, Izmir,
  • Orkun Ilgen Department of Obstetrics and Gynecology, Dokuz Eylul University School of Medicine, Izmir, TURKEY
  • Göksenil Bulbul Department of Pathology, Dokuz Eylul University School of Medicine, Izmir, TURKEY
  • Bahadır Saatli Department of Obstetrics and Gynecology, Dokuz Eylul University School of Medicine, Izmir,
  • Cagnur Ulukus Department of Pathology, Dokuz Eylul University School of Medicine, Izmir, TURKEY

DOI:

https://doi.org/10.46328/aejog.v3i3.99

Keywords:

sertoli-leydig cell tumor, ovarian hilus cell hyperplasia, postmenopausal virilization, sex-cord-stromal tumors

Abstract

Objective; We present a case report regarding a 71-year-old woman with postmenopausal virilization caused by ovarian hilus cell hyperplasia and Sertoli-Leydig cell tumor who was suffered from hair loss, clitoromegaly and hirsutism.

Case Report; The patient’s plasma testosterone levels were high.  In the MRI examination, a nodular formation of 20x26mm in size was observed in the right ovary. At the transvaginal ultrasound, a cystic mass of 28x28mm was seen in the right ovary. Then we performed a total laparoscopic hysterectomy and bilateral salpingo-oophorectomy. The final pathology showed a poorly differentiated Sertoli Leydig cell tumor at the right ovary and hilus cell hyperplasia at the left ovary. Sertoli-Leydig cell tumors, which are relatively less common, are extremely rare to be seen in the postmenopausal period.

Conclusion; What distinguishes this case from others is that Sertoli-Leydig cell tumor and hilus cell hyperplasia may cause virilization symptoms together, in addition to its prevalence in advanced age.

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Published

2021-12-22

How to Cite

1.
Ertan B, Ozgozen E, Ilgen O, Bulbul G, Saatli B, Ulukus C. Ovarian Hilus Cell Hyperplasia and Sertoli-Leydig Cell Tumor in a Patient with Postmenopausal Virilization: a Rare Case Report. Aegean J Obstet Gynecol [Internet]. 2021 Dec. 22 [cited 2022 Jan. 16];3(3):83-6. Available from: https://aejog.com/index.php/aejog/article/view/99