How the nitric oxide and antioxidant enzymes work in the placental tissues of pregnant women with COVID 19 disease?
DOI:
https://doi.org/10.46328/aejog.v4i2.111Keywords:
pregnant, Covid19, placenta tissue, blood plasmaAbstract
Objective: The aim of this study to examine the oxidative stress parameters in placental tissues and blood plasmas of pregnant women.
Materials and Methods: The biochemical parameters were examined in 37 pregnant women with covid disease, 37 pregnant women who had covid, and 37 healthy pregnant women. The amounts of lipid peroxidation (LPO), glutathione (GSH), nitric oxide (NOx) and catalase (CAT), superoxide dismutase (SOD) enzyme activities were measured in each tissue and blood plasma.
Results:The LPO levels increased in the pregnant woman who has had covid 19 compared with healthy pregnant. Likewise, the LPO levels increased in pregnant women who were negative at the time of delivery. While the amount of glutathione was high in healthy placental tissues, it was found to be quite low in covid 19 positive tissues. While the enzyme activities of SOD and NOx are quite high in placental tissues of healthy pregnant women, they are significantly low in covid positive and negative pregnant tissues. While the CAT enzymes activities, another antioxidant enzyme, was at a very low level in healthy placental tissues compared to SOD enzyme, it was significantly increased in positive pregnant placental tissues.
Conclusion: The antioxidant enzyme activities and amounts show significant differences between groups in placental tissues. The changes in enzyme rates in placental tissues are proportional to blood plasma results.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Ozlem Aydin Berktas, Sadettin Oguzhan Tutar, E. Gulceri Gulec Peker, Candan Kaya
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
AEJOG is an open-access journal which means that through the internet; freely accessible, readable, downloaded, copied, distributed, printed, scanned, linked to full texts, indexed, transferred to the software as data and used for any legal purpose, without financial, legal and technical obstacles. The only authority on reproduction and distribution and the sole copyright role in this field; has been given to authors therefore they can have control over the integrity of their work, so that they are properly recognized and cited. This is in accordance with the BOAI definition of open access.
The content in Aegean Journal of Obstetrics and Gynecology (AEJOG) is protected by copyright. All copyrights of the submitted articles are transferred to the Aegean Journal of Obstetrics and Gynecology within the national and international regulations at the beginning of the evaluation process. Upon submission of their article, authors are requested to complete an assignment of copyright release form. Authors should acknowledge that they will not submit their manuscript to another journal, publish in any other language, or allow a third party to use the article without the written consent of the Aegean Journal of Obstetrics and Gynecology. When an article is published on AEJOG, it is read and reused for free as soon as it is published under a Creative Commons Attribution-NonCommercial 4.0 (CC BY NC 4.0) license. In case the article is rejected, all copyrights are given back to the authors.
The content of the article and all legal proceedings against the journal, if any, are the responsibility of the author. In addition, all financial and legal liability for the copyright of the presented tables, figures and other visual materials protected by law belongs to the authors. It is the responsibility of the corresponding author to report authors scientific contributions and responsibilities regarding the article. In case of any conflict of interest, it is the responsibility of the authors to indicate the conflict of interest in the Disclosure part of the article. Author names will be published as they are listed on the submitted Title page.
